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Precision theranostics in cervical Cancer: Harnessing stimuli-responsive hydrogels for tumor

Yu Zhang1,2,3, Yueda Lu1,2,3, Sidi Li2

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, 230022, PR China.

Materials Today. Bio
|November 10, 2025
PubMed

Insights

Stimuli-responsive hydrogels offer precise cervical cancer treatment by targeting the tumor microenvironment. These smart materials enhance drug delivery, diagnostics, and reduce side effects for better patient outcomes.

Area of Science:

  • Biomaterials Science
  • Oncology
  • Nanotechnology

Background:

  • Cervical cancer presents a global health challenge, with conventional treatments facing limitations like drug resistance and toxicity.
  • Stimuli-responsive hydrogels are emerging as advanced platforms for precision oncology.

Purpose of the Study:

  • To review stimuli-responsive hydrogels as precision theranostic platforms for cervical cancer.
  • To highlight their ability to target the unique tumor microenvironment (TME).

Main Methods:

  • Systematic categorization of hydrogel systems based on response mechanisms (pH, temperature, enzymes, light, magnetic fields, redox).
  • Alignment of hydrogel systems with clinical applications: chemotherapy, gene therapy, immunotherapy, and diagnostics.
  • Exploration of integrated advanced technologies: 4D printing, organoid models, and artificial intelligence (AI).

Main Results:

  • Hydrogels offer spatiotemporally controlled drug delivery and multimodal theranostic functions.
  • These platforms dynamically interact with the cervical cancer TME.
  • Integration with AI and 4D printing enables personalized treatment and dynamic adaptability.

Conclusions:

  • Stimuli-responsive hydrogels represent a promising strategy for enhancing therapeutic precision in cervical cancer.
  • These smart materials can reduce off-target effects and improve diagnostic sensitivity.
  • This review provides insights into designing advanced hydrogels for improved cervical cancer management.
Keywords:
Cervical cancerPrecision medicineSmart drug deliveryStimuli-responsive hydrogelTheranostics

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