Palladium-catalyzed amidocarbonylation of thioethers: access to α-amide-substituted thioether derivatives
Xudong Mao1,2, Le-Cheng Wang1,2, Xiao-Feng Wu1,2
1Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian China Xiao-Feng.Wu@catalysis.de xwu2020@dicp.ac.cn.
Abstract:
Thioethers play a crucial role as structural components in a wide range of natural products, pharmaceuticals, and industrial materials, influencing their chemical characteristics and biological functions. Herein, we report a palladium-catalyzed aminocarbonylation reaction of thioethers with amines as nucleophiles. This palladium-catalyzed carbonylation reaction features a wide substrate scope and functional group tolerance, enabling the efficient C(sp3)-H aminocarbonylation of thioethers to afford the corresponding amides in good yields.
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