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Efficacy Of A Ceftazidime-loaded Nanofiber Insert In Treating Pseudomonas Aeruginosa-induced Corneal Ulcers: An Animal Model.

Home
Research Domains
Biomedical And Clinical Sciences
Paediatrics
Infant And Child Health
Efficacy Of A Ceftazidime-loaded Nanofiber Insert In Treating Pseudomonas Aeruginosa-induced Corneal Ulcers: An Animal Model.

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Efficacy of a Ceftazidime-loaded Nanofiber Insert in Treating Pseudomonas aeruginosa-induced Corneal Ulcers: An Animal Model.

Shahla Mirzaeei^1,2,3, Mojtaba Eidizadeh^4,5, Abbas Khosravi^4,5

¹Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Journal of Ophthalmic & Vision Research

|November 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Ceftazidime-containing nanofibers effectively treated Pseudomonas aeruginosa-induced corneal ulcers in rabbits. This nanodrug delivery system shows promise for ocular infections.

Keywords:

Corneal Ulcer Drug Delivery Nanofiber Insert Animal Model

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Area of Science:

Ophthalmology
Nanotechnology
Microbiology

Background:

Corneal ulcers caused by Pseudomonas aeruginosa are a significant cause of vision impairment.
Current treatments may have limitations in efficacy and delivery.

Purpose of the Study:

To evaluate the efficacy of ceftazidime-containing nanofibers in treating Pseudomonas aeruginosa-induced corneal ulcers.
To assess the safety and potential of this nanodrug delivery system for ocular applications.

Main Methods:

A rabbit model of Pseudomonas aeruginosa-induced corneal ulcers was used.
Animals were divided into two groups: ceftazidime nanofiber treatment and control (no treatment).
Clinical examinations and bacterial cultures were performed to assess treatment outcomes.

Main Results:

The ceftazidime nanofiber group showed significant improvement, with complete ulcer healing by day 9.
Control group eyes exhibited worsening ulceration.
A statistically significant difference in corneal ulcer scores was observed between groups (P < 0.001).

Conclusions:

Ceftazidime-loaded nanofibers are effective in treating Pseudomonas aeruginosa corneal ulcers.
This nanodrug delivery system offers a promising approach for ocular drug delivery.