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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Coronary Stents: All Those Trials.

Margaret Mary Glazier1, James J Glazier2,3

  • 1Department of Medicine, Tufts Medical Center, Boston, Massachusetts.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 10, 2025
PubMed
Summary
This summary is machine-generated.

Coronary stents have evolved significantly, improving angioplasty outcomes by reducing restenosis and abrupt closure. Newer drug-eluting stents offer low thrombosis rates, but surgery may be better for complex coronary artery disease.

Keywords:
acute coronary dissectionbare metal coronary stentsbioresorbable stentscoronary angioplastycoronary artery diseasecoronary restenosisdrug-eluting coronary stentsstents for coronary artery disease

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomaterials Engineering

Background:

  • Coronary stents were developed to address limitations of balloon angioplasty, specifically high restenosis rates and abrupt vessel closure.
  • Early trials confirmed stents' efficacy in scaffolding arteries and reducing restenosis compared to balloon angioplasty alone.

Purpose of the Study:

  • To review the evolution of coronary stent technology and its impact on patient outcomes.
  • To evaluate the effectiveness and safety of various stent types, including bare metal, drug-eluting, and bioresorbable stents.
  • To compare percutaneous coronary intervention (PCI) with drug-eluting stents versus coronary artery bypass surgery (CABS) for complex coronary artery disease.

Main Methods:

  • Review of pivotal clinical trials including BENESTENT-I, STRESS, SIRIUS, ABSORB II, and SYNTAX.
  • Analysis of restenosis rates, stent thrombosis, and revascularization needs across different stent generations.
  • Comparison of PCI outcomes with surgical revascularization in complex multi-vessel and left main coronary artery disease.

Main Results:

  • Stents significantly reduced restenosis rates compared to balloon angioplasty.
  • First-generation drug-eluting stents (DES) lowered target lesion revascularization but raised concerns about stent thrombosis.
  • Second-generation DES demonstrated very low stent thrombosis rates (<1%). Bioresorbable stents showed diminished promise.
  • The SYNTAX trial indicated CABS may be superior to PCI with DES for left main and multi-vessel disease.

Conclusions:

  • Coronary stent technology has advanced, offering improved outcomes for patients with coronary artery disease.
  • While DES have become standard, careful patient selection is crucial, with CABS remaining a preferred option for complex disease.
  • Ongoing research continues to refine stent design and optimize treatment strategies for coronary artery disease.