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The History of Coronary Artery Disease

Andrew J Gorton1, Sibu P Saha1

  • 1Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 10, 2025
PubMed

Insights

Coronary artery disease (CAD) has ancient origins, evolving from early atherosclerosis evidence to modern treatments like percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Continued innovation is vital for addressing this global health challenge.

Area of Science:

  • Cardiovascular Medicine
  • Medical History

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Evidence of atherosclerosis dates back to ancient civilizations, challenging its perception as a modern disease.

Purpose of the Study:

  • To review the historical evolution of understanding, diagnosis, and treatment of CAD.
  • To highlight key milestones from ancient evidence to modern interventions.

Main Methods:

  • Historical review of medical literature and evidence.
  • Tracing the progression of diagnostic techniques and therapeutic interventions.
  • Examining the development of pharmacological and surgical treatments for CAD.

Main Results:

  • Early evidence of atherosclerosis found in ancient mummies.
  • Pioneering contributions from medical and surgical experts throughout history.
  • Development of innovative treatments including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG).
  • Evolution of medical therapies such as digitalis, nitrates, aspirin, beta blockers, and statins.

Conclusions:

  • CAD's historical trajectory offers critical insights for future cardiovascular medicine.
  • Despite advancements, CAD remains a significant public health issue requiring ongoing innovation.
  • Understanding the past is essential for shaping future prevention, diagnosis, and treatment strategies.

Keywords:
angina pectoriscoronary angiographycoronary artery bypass graftingcoronary artery diseasepercutaneous coronary intervention

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