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Aneurysmal Coronary Artery Disease: A Contemporary and Comprehensive Review

Mohamad Mubder1, Noyan Ramazani2, Vasiliki Tasouli-Drakou2

  • 1University Medical Center, Las Vegas, Nevada.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 10, 2025
PubMed

Insights

Coronary artery aneurysms (CAAs) are focal enlargements of coronary arteries. This review covers their causes, potential complications, and updated diagnostic and management strategies.

Area of Science:

  • Cardiology
  • Vascular Medicine

Background:

  • Coronary artery aneurysm (CAA) is defined as a focal enlargement exceeding 1.5 times the adjacent normal segment.
  • Prevalence varies (0.2-10%), with male predominance and a predilection for the right coronary artery.
  • Atherosclerosis (adults) and Kawasaki disease (children) are primary causes.

Purpose of the Study:

  • To provide a comprehensive review of current knowledge on coronary artery aneurysms.
  • To highlight recent advances in the diagnosis and management of CAA.

Main Methods:

  • Review of existing literature on coronary artery aneurysms.
  • Discussion of diagnostic modalities including coronary angiography, CT angiography, and MR angiography.
  • Analysis of current management strategies.

Main Results:

  • While often asymptomatic, CAAs can lead to angina, myocardial infarction, rupture, and embolization.
  • Advancements in cardiac imaging enhance detection, characterization, risk stratification, and management planning.
  • Management is tailored to aneurysm size, location, symptoms, and complications.

Conclusions:

  • Coronary artery aneurysms require careful evaluation due to potential severe complications.
  • Modern imaging techniques improve diagnostic accuracy and aid in personalized treatment planning.
  • A multidisciplinary approach involving medical, percutaneous, and surgical options is crucial for effective management.

Keywords:
Kawasaki diseasecoronary artery aneurysmcoronary artery dilatationcoronary artery ectasiacoronary artery thrombosisgiant coronary artery aneurysm

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