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Warm Autoimmune Haemolytic Anaemia Management in Asia-Pacific: A Delphi Panel Expert Consensus and Systematic
Phil Choi1, Alberta Hoi2, Rong Fu3
1Caberra Hospital Canberra Australia.
Ejhaem
|November 10, 2025
Summary
This study assessed warm autoimmune hemolytic anemia (wAIHA) in the Asia-Pacific. It highlights the need for region-specific treatment guidelines and improved disease awareness to enhance patient care.
Area of Science:
- Hematology
- Immunology
- Clinical Research
Background:
- Warm autoimmune hemolytic anemia (wAIHA) presents a significant clinical challenge.
- Understanding regional treatment variations is crucial for effective patient management.
Purpose of the Study:
- To evaluate the burden and treatment practices of wAIHA in the Asia-Pacific (APAC) region.
- To develop consensus recommendations for wAIHA diagnosis and treatment.
Main Methods:
- A systematic literature review of observational studies was performed.
- A Delphi panel convened to establish consensus on diagnosis, treatment goals, and algorithms.
- Key challenges and research priorities were identified.
Main Results:
- Corticosteroids are the primary first-line treatment, with high response rates (81%-96%) but significant relapse rates (18%-45%).
- Routine screening for underlying conditions and early interventions were recommended.
- Restricted rituximab access and physician awareness gaps were identified as key challenges in the APAC region.
Conclusions:
- Evidence-based, regionally adaptable treatment algorithms for wAIHA are essential in the APAC region.
- Addressing data gaps in epidemiology, outcomes, and quality of life is critical for improving patient care.
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