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Published on: December 6, 2016
Effect of Propofol on Postoperative Sleep Quality in Patients Undergoing Elective Cesarean Section with Spinal
Jie Zhou1, Bingwei Hu1, Yu Zhang1
1Department of Anesthesiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China.
Purpose:
To assess the impact of propofol on postoperative sleep quality in patients undergoing spinal anesthesia for cesarean section.
Patients And Methods:
This study included a total of 245 patients, aged over 18 yr, who underwent elective cesarean section under spinal anesthesia from 1 January 2024 to 31 December 2024. Outcomes were compared between the propofol group, which received propofol after infant delivery, and the control group, which received no intravenous anesthetics. Primary and secondary outcomes were postoperative sleep quality and depressive symptoms, evaluated using the Pittsburgh Sleep Quality Index (PSQI) and Edinburgh Postnatal Depression Scale (EPDS) at 30 days post-surgery. Propensity-score matching ensured balanced baseline characteristics.
Results:
Following propensity score matching, 29 patients per group were included in this study. After matching, the propofol group showed significantly lower PSQI scores (8.3 ± 3.4 vs 10.9 ± 3.1; mean difference -2.6, 95% CI: -3.1 to -2.1; P<0.001) and lower EPDS scores (7.9 ± 3.0 vs 10.2 ± 3.1; mean difference -2.3, 95% CI: -3.0 to -1.7; P<0.001) compared to the control group on the 30th day after surgery.
Conclusion:
Using propofol following extraction of the infant was associated with lower incidence of postoperative sleep disorders in patients undergoing spinal anesthesia for cesarean section.
Clinical Trial Registration Number:
ChiCTR2500097811.
Registration Date:
02/26/2025.
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