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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Sputum Studies II: Culture and Sensitivity01:20

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BronchStop Study Protocol, Season 2.

Shaun O'Hagan1, Steve Cunningham2,3, Simon B Drysdale4,5

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Summary
This summary is machine-generated.

Maternal respiratory syncytial virus (RSV) vaccination is being assessed for infant protection against severe respiratory infections. This study will evaluate vaccine effectiveness and uptake factors in the UK. Findings will inform public health strategies.

Keywords:
Respiratory syncytial virus; maternal vaccination; respiratory disease; infants

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Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Serious respiratory tract infections in children increased post-lockdown, prompting the BronchStart study.
  • BronchStart data informed the UK's Joint Committee on Vaccination and Immunisation (JCVI) recommendation for maternal respiratory syncytial virus (RSV) vaccination.
  • Maternal RSV vaccination was rolled out in the UK in August/September 2024 for pregnant women at ≥28 weeks gestation.

Purpose of the Study:

  • To assess the effectiveness of maternal RSV vaccination against infant hospitalization for RSV-associated acute lower respiratory tract infection (ALRI).
  • To understand factors influencing maternal vaccine uptake through a survey administered to mothers.
  • To investigate residual causes of severe infant respiratory disease in the post-vaccination era.

Main Methods:

  • A UK-wide, multi-centre, prospective, test-negative case control study will be conducted in the 2025-2026 winter season.
  • Infants under 6 months born to vaccinated mothers will be recruited.
  • Maternal surveys, vaccination record access, and infant virological sample analysis (whole genome sequencing, rRT-PCR) will be employed.

Main Results:

  • This section is not applicable as the study is prospective and results are not yet available.

Conclusions:

  • This study will provide crucial data on the effectiveness of maternal RSV vaccination in protecting infants against severe respiratory illness.
  • Findings will inform ongoing public health policy and vaccination strategies, including recommendations to advisory groups like JCVI and the World Health Organization.