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Stimuli-Responsive MXene Nanomaterials for Advanced Antitumor Drug Delivery Systems
Peng Deng1, Zhihong Ling1, Fei Fang2
1Department of Oncology, The Fourth People's Hospital of Sichuan Province, Chengdu, People's Republic of China.
International Journal of Nanomedicine
|November 10, 2025
Summary
MXene nanomaterials offer advanced antitumor drug delivery by overcoming traditional therapy limitations. This review explores MXene-based systems responsive to various stimuli for enhanced cancer treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Traditional cancer therapies face challenges like systemic toxicity and poor tumor targeting.
- MXene (a 2D nanomaterial) presents unique properties for drug delivery, including high surface area and photothermal efficiency.
- MXene-based nanocarriers are emerging as a promising alternative for improved cancer treatment.
Purpose of the Study:
- To review intelligent responsive nano-drug delivery systems utilizing MXene nanomaterials.
- To summarize research on MXene nanomaterials responsive to endogenous (pH, redox) and exogenous (photoheat, ultrasound) stimuli.
- To provide insights for developing effective and safe MXene-based antitumor agents.
Main Methods:
- Review of existing literature on MXene nanomaterials in drug delivery.
- Analysis of MXene-based systems designed for stimuli-responsive drug release.
- Categorization of MXene nanomaterials based on response mechanisms (endogenous, exogenous, multi-stimulus).
Main Results:
- MXene nanomaterials demonstrate significant potential as carriers for targeted antitumor drug delivery.
- Stimuli-responsive MXene systems show enhanced drug release profiles tailored to tumor microenvironments.
- Multistimulus-responsive MXene platforms offer synergistic therapeutic effects and improved efficacy.
Conclusions:
- MXene-based nano-drug delivery systems represent a significant advancement in cancer therapy.
- Intelligent responsive designs enhance drug efficacy and minimize off-target side effects.
- Further research into MXene nanomaterials will drive the development of next-generation cancer treatments.
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