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s-Block Atomic Calcium Sites Boost Biomimetic Hydrolysis for Personal Protection.

Wenxuan Jiang1, Yu Wu1, Weiqing Xu1

  • 1State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.

Nano Letters
|November 10, 2025
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Summary
This summary is machine-generated.

A novel nanozyme, Ca-CeO2, mimics paraoxonase 1 for rapid organophosphorus compound detoxification. This breakthrough enables the development of advanced personal protective equipment for enhanced safety against neurotoxic agents.

Keywords:
Atomic Calcium SitesBiomimetic HydrolysisNanozymesOrganophosphorus CompoundsPersonal Protection

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Area of Science:

  • Materials Science
  • Biochemistry
  • Environmental Science

Background:

  • Organophosphorus compounds (OPs) pose significant neurotoxic risks.
  • Mammalian detoxification via paraoxonase 1 is often inefficient.
  • A need exists for robust nanozymes in artificial OP metabolism systems.

Purpose of the Study:

  • To design a nanozyme mimicking paraoxonase 1 for efficient organophosphorus compound hydrolysis.
  • To develop an artificial metabolic system for rapid OP detoxification.
  • To integrate the nanozyme into personal protective equipment.

Main Methods:

  • Synthesis of ceria nanozyme anchored with s-block atomic calcium sites (Ca-CeO2).
  • Characterization of Ca-CeO2's Lewis acid properties and orbital coupling.
  • Evaluation of Ca-CeO2's hydrolytic detoxification efficiency and half-life.
  • Integration of Ca-CeO2 into a protective mask.

Main Results:

  • Ca-CeO2 demonstrated efficient hydrolytic detoxification of OPs with an ultrashort half-life of 1.64 min.
  • The s-block Ca site enhanced substrate adsorption and nucleophilic attack.
  • A Ca-CeO2-integrated protective mask provided effective personal protection.

Conclusions:

  • Ca-CeO2 nanozymes offer a promising strategy for rapid organophosphorus compound detoxification.
  • Mimicking paraoxonase 1 with nanozymes can create effective artificial metabolic systems.
  • This technology holds potential for advanced personal protective equipment against neurotoxins.