Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

853
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
853
Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

568
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
568

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.

The New England journal of medicine·2026
Same author

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Efficacy and Safety of Somapacitan vs Daily Growth Hormone in Children with Growth Hormone Deficiency: A Pooled Analysis of Randomised Trial Data.

Hormone research in paediatrics·2026
Same author

Deciphering the role of adipose tissue microbial DNA in obesity-related metabolic dysfunction.

The Journal of clinical endocrinology and metabolism·2026
Same author

Thyroid hormones and energy metabolism in amyotrophic lateral sclerosis.

Brain communications·2026
Same author

PPAR-δ is a potential modulator of central carbon metabolism in human adipocytes.

Bioinformation·2026

Related Experiment Video

Updated: Jan 11, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.2K

Optimizing Type 1 Diabetes Screening in People With Family History: A German Perspective.

Thomas Danne1,2, Thomas M Kapellen3, Sebastian A Widholz4

  • 1NOVA Medical School, Lisbon, Portugal.

Journal of Diabetes Science and Technology
|November 10, 2025
PubMed
Summary

Germany

Keywords:
German perspectiveantibody screeningautoimmune diseasediabetesfamilial autoimmune diseasefirst-degree relativesscreeningtype 1 diabetes

More Related Videos

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

3.0K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.0K

Related Experiment Videos

Last Updated: Jan 11, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.2K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

3.0K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.0K

Area of Science:

  • Endocrinology
  • Immunology
  • Genetics

Background:

  • Individuals with a family history of type 1 diabetes (T1D) have a significantly higher risk.
  • Early detection of T1D is possible through islet autoantibody (IAb) testing before clinical onset.
  • Rising global T1D incidence necessitates proactive screening strategies.

Purpose of the Study:

  • To outline Germany's strategy for early T1D detection and management in high-risk family members.
  • To illustrate implementation lessons using data from the German Fr1da study.
  • To discuss challenges and opportunities for nationwide T1D screening integration.

Main Methods:

  • Review of Germany's T1D screening strategy for family history individuals.
  • Analysis of findings from the German Fr1da general-population study.
  • Inclusion of recommendations from international screening efforts.

Main Results:

  • Family history and genetic factors increase T1D risk.
  • Early detection via IAb testing can reduce diabetic ketoacidosis (DKA) rates.
  • Disease-modifying therapies (DMTs) provide an incentive for screening.

Conclusions:

  • Early detection and monitoring of at-risk relatives are critical for mitigating T1D burden.
  • Leveraging healthcare systems can enable cost-effective, nationwide T1D screening.
  • Addressing practical barriers is essential for successful family-based T1D screening programs.