Related Experiment Video
Updated: Jan 11, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
1.0K
Novel Wound Care Practices in Bullous Pemphigoid: A Systematic Review
Ted Jacoby1, Danielle Yee1, Ralina Karagenova2
1Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA.
Summary
This review found that advanced wound care, including ozone liquid dressing and recombinant human type XVII collagen, can improve healing and reduce pain in bullous pemphigoid patients.
Area of Science:
- Dermatology
- Wound Healing
- Autoimmune Blistering Diseases
Background:
- Bullous pemphigoid is a common autoimmune blistering disease impacting patient morbidity.
- Optimal wound care strategies for bullous pemphigoid lack consensus and literature support.
Purpose of the Study:
- To critically appraise evidence on wound care practices in bullous pemphigoid.
- To identify interventions that improve healing time, infection control, and pain management.
Main Methods:
- Systematic review and meta-analysis of literature from PubMed, Embase, and Web of Science.
- Screening by two independent reviewers, with discrepancies resolved by consensus.
- Inclusion of three studies evaluating ozone liquid dressing, recombinant human type XVII collagen, and berberine-based dressings.
Main Results:
- Ozone liquid dressing (OLD) demonstrated faster healing, reduced infection, and improved pain control.
- Recombinant human type XVII collagen (RHCXVII) hydrogel accelerated healing, blister regression, and increased patient satisfaction.
- Berberine-based dressings showed symptomatic benefit as a topical adjunct.
Conclusions:
- Wound care plays an emerging role in bullous pemphigoid management.
- Further large-scale, multicentre randomized controlled trials are needed to establish standardized guidelines for wound care modalities.
