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Serum heparin binding protein as a biomarker for sepsis in pyogenic liver abscess patients
Caicai Zhang1, Baoyong Zhang2, Qishuang Song1
1Infectious Disease Department, The Second Affiliated Hospital of the Shandong First Medical University, Taian, Shandong, China.
Background:
Pyogenic liver abscess (PLA) is a severe infectious condition characterized by hepatic parenchymal pus accumulation, posing diagnostic and management challenges despite medical advances. Sepsis ensuing from PLA signifies a critical clinical scenario with notable morbidity and mortality implications.
Methods:
A retrospective analysis encompassing 202 PLA patients over five years discerned 79 with sepsis (PLAS group) and 123 without sepsis (PLA group). Baseline characteristics, pathogen distribution, and serum heparin-binding protein (HBP) levels were assessed, alongside statistical analyses including multivariate logistic regression and receiver operating characteristic (ROC) curve analysis.
Results:
Significant differences in biliary tract disease prevalence, plasma procalcitonin (PCT), and blood lactate levels were noted between PLAS and PLA groups, suggesting potential sepsis indicators in PLA patients. Klebsiella pneumoniae predominated among cultured pathogens, with no significant difference between septic and non-septic groups. Serum HBP levels were markedly elevated in PLAS patients, exhibiting positive correlations with sepsis severity and serving as an independent sepsis risk factor. ROC analysis demonstrated enhanced diagnostic performance for sepsis when combining serum HBP, PCT, and blood lactate levels.
Conclusion:
Serum HBP provides diagnostic and prognostic value for sepsis in PLA patients, and its combination with established biomarkers improves early detection and management.
