Cardiac magnetic resonance assessment of mitral annular disjunction in children: insights from T1 mapping and feature-tracking strain analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric mitral annular disjunction shows early heart muscle changes like reduced strain and higher native T1/extracellular volume. Cardiac magnetic resonance (CMR) detects these subtle signs of remodeling in children.
Area Of Science
- Cardiology
- Pediatric Cardiology
- Cardiovascular Imaging
Background
- Mitral annular disjunction (MAD) is a structural heart abnormality linked to myocardial remodeling.
- While adult MAD is studied, pediatric data is limited.
Purpose Of The Study
- To evaluate early myocardial structural and functional changes in pediatric MAD.
- Utilize cardiac magnetic resonance (CMR) feature-tracking strain and parametric mapping.
Main Methods
- Retrospective study of 32 pediatric MAD patients and 16 controls using CMR.
- Assessed cine imaging, late gadolinium enhancement, T1 mapping, extracellular volume, and strain analysis.
- Evaluated Holter data for ventricular ectopy.
Main Results
- MAD patients had reduced global, basal, and segmental strain values.
- Elevated native T1 and extracellular volume observed in the MAD group.
- Late gadolinium enhancement (21.9%) and ventricular ectopy (48.3%) were noted.
Conclusions
- Pediatric MAD is associated with early myocardial alterations, including impaired deformation and elevated native T1/extracellular volume.
- Subclinical myocardial remodeling may start in childhood.
- CMR is effective in detecting these subtle changes in pediatric MAD.
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