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Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish

Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish

Published on: October 27, 2017

Update on pellucid marginal degeneration.

Ibraim V Vieira^1,2, Victoria H Fan¹, Charles Q Yu^3,4

¹Department of Ophthalmology, Byers Eye Institute at Stanford, 94303, Palo Alto, CA, USA.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|November 10, 2025

Summary

This summary is machine-generated.

Recent advances in diagnosing and treating pellucid marginal degeneration (PMD) include improved corneal imaging and biomechanical assessments. Contact lenses and lamellar surgery are key treatments, with ongoing research into corneal cross-linking (CXL).

Keywords:

Collagen Cornea Crosslinking Degeneration Ectasia Keratoconus Marginal Pellucid

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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Corneal Ectasias
Medical Technology

Background:

Pellucid marginal degeneration (PMD) is a progressive corneal ectasia.
Accurate diagnosis and effective management are crucial for visual preservation.

Purpose of the Study:

Review recent (2014-2024) advancements in PMD diagnosis and treatment.
Focus on imaging, biomechanics, contact lenses, surgery, and cataract surgery implications.

Main Methods:

Comprehensive literature search of PubMed, Scopus, and Embase (Jan 2014-Nov 2024).
Inclusion of 50 eligible articles after dual independent screening.

Main Results:

Advanced imaging and biomechanical assessments improve PMD diagnosis and differentiation.
Rigid contact lenses offer conservative management; modified corneal cross-linking (CXL) shows stabilization potential.
Lamellar keratoplasty provides good outcomes; wedge resection requires further study.
Toric intraocular lenses (IOLs) may correct astigmatism in PMD patients undergoing cataract surgery.

Conclusions:

PMD diagnosis and treatment have evolved significantly over the past decade.
Enhanced imaging and biomechanical assessments are vital for accurate diagnosis.
Contact lenses and lamellar surgery remain primary treatments; CXL protocols warrant further clinical investigation.