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Updated: Jul 9, 2026
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Non-colorectal liver metastases-Indications and treatment approach]
Franziska A Meister1, Oliver Beetz1, Felix Oldhafer1
1Klinik für Allgemein‑, Viszeral‑, Kinder- und Transplantationschirurgie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
Background:
While standardized treatment recommendations exist for colorectal liver metastases, non-colorectal liver metastases (NCRLM) remain a treatment challenge due to the heterogeneous biology and the lack of evidence-based guidelines.
Material And Methods:
This review article considers current systematic reviews, retrospective cohort studies and meta-analyses addressing surgical resection and local ablation of NCRLM.
Results:
Retrospective data show that selected patients with NCRLM can benefit from local treatment. Favorable prognostic factors include a limited number of oligometastases, achievement of an R0 resection and the absence of extrahepatic tumor manifestations.
Discussion:
In view of the limited evidence base, recent advances in minimally invasive surgery and modern systemic treatment, prospective studies are essential to validly define the oncological relevance of local treatment strategies for liver metastases.
