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Motor placebo effect in obesity: how ergogenic aids can decrease fatigue and improve motor performance.

Valeria Volpino¹, Maria Elena Navarra¹, Federica Scarpina^2,3

¹Department of Neurosciences, University of Turin, Via Cherasco, 15, 10126, Turin, Italy.

Eating and Weight Disorders : EWD

|November 10, 2025

Summary

This summary is machine-generated.

Positive expectations from a placebo treatment can reduce perceived fatigue and improve motor performance in individuals with obesity. This sham electrical stimulation enhanced endurance and reduced perceived exertion, suggesting psychological factors play a key role.

Keywords:

Fatigue Motor performance Obesity Placebo Readiness potential

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Area of Science:

Exercise Science
Neuroscience
Obesity Research

Background:

Obesity is linked to higher perceived fatigue and lower physical activity levels.
Understanding interventions to mitigate fatigue and improve motor function in obesity is crucial.

Purpose of the Study:

To investigate if a placebo ergogenic treatment can reduce perceived exertion and enhance motor performance in individuals with obesity.
To assess the impact of positive expectations on fatigue and motor control.

Main Methods:

A randomized controlled trial involving 44 participants with obesity.
Participants received either a placebo (sham transcutaneous electrical stimulation with positive suggestions) or were in a control group.
Motor performance (endurance, perceived exertion, Readiness Potential) was measured during a finger-flexion task.

Main Results:

The placebo group showed smaller decreases in repetitions and perceived exertion load compared to controls.
The placebo group also exhibited a smaller increase in the late Readiness Potential amplitude.
These results indicate a reduction in perceived fatigue within the placebo group.

Conclusions:

Positive expectations, even from a placebo, can effectively alleviate perceived fatigue in individuals with obesity.
These psychological factors also reduce the neural cost associated with motor preparation.
The study highlights the potential of non-pharmacological interventions targeting psychological aspects in managing obesity-related fatigue and performance deficits.