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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Cost-Effective Components of a Patient-Reported Symptom Monitoring System for Chemotherapy.

Kathi Mooney¹, Minkyoung Yoo², Elizabeth S Sloss¹

¹University of Utah College of Nursing, Salt Lake City.

JAMA Network Open

|November 10, 2025

Summary

This summary is machine-generated.

The complete Symptom Care at Home (SCH) intervention, an electronic patient-reported outcome (ePRO) system, proved most cost-effective for managing cancer symptom burden. Comprehensive ePRO systems enhance quality of care and reduce costs.

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Area of Science:

Oncology
Health Economics
Digital Health

Background:

Electronic patient-reported outcome (ePRO) systems help manage cancer symptom burden.
Few studies have assessed the cost-effectiveness of individual ePRO components.

Purpose of the Study:

To determine the most cost-effective components of the Symptom Care at Home (SCH) ePRO system for adult cancer patients.
To evaluate combinations of automated self-management coaching and nurse practitioner (NP) follow-up.

Main Methods:

Economic evaluation using data from a 5-group randomized clinical trial.
Markov simulation models and incremental cost-effectiveness ratios (ICERs) were used.
Costs included symptom burden, hospitalizations, emergency visits, and system development/operations.

Main Results:

The complete SCH intervention demonstrated the highest cost-effectiveness.
The ICER for complete SCH versus NP-only follow-up was $4957.
Complete SCH had the highest probability of being cost-effective across various willingness-to-pay values.

Conclusions:

The complete SCH intervention, integrating all components, is the most cost-effective strategy.
Comprehensive ePRO systems improve patient quality of life by reducing symptom burden.
Value-driven healthcare supports the use of integrated ePRO systems for cancer symptom management.