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Artificial Intelligence Chatbots and Their Responses to Most Searched Spanish Cancer Questions.

En Cheng^1,2, Jesus D Anampa^3,4, Carolina Bernabe-Ramirez^3,4

¹Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.

Cancer Medicine

|November 10, 2025

Summary

AI chatbots provide good quality answers to Spanish cancer questions, but lack actionable information and are difficult to read. Performance is similar across free and paid versions.

Keywords:

Hispanic Americans artificial intelligence health literacy natural language processing neoplasms patient education

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Area of Science:

Oncology
Artificial Intelligence
Health Informatics

Background:

Artificial intelligence (AI) chatbots excel at answering English cancer-related queries.
The performance of AI chatbots for Spanish-language cancer information is largely unknown.
Differences in AI chatbot performance may exist between free and paywall versions.

Purpose of the Study:

To evaluate the quality, actionability, and readability of popular AI chatbots for Spanish cancer questions.
To compare the performance of free versus paywall AI chatbot versions.

Main Methods:

Six popular AI chatbots were assessed.
Evaluated responses to the 15 most searched Spanish questions on breast, prostate, and colon cancer.
Assessed response quality (1-5 points), actionability (0-100%), and readability (grade level).

Main Results:

Overall AI chatbot response quality was good (mean 3.5/5).
Response actionability was low (mean 35.6%), and readability was at a high-school level (mean 9.2 grades).
No significant differences in quality, actionability, or readability were found between free and paywall chatbot versions (p > 0.05).

Conclusions:

AI chatbots can generate good quality responses to Spanish cancer queries, irrespective of version (free vs. paywall).
Significant improvements in response actionability and readability are necessary for effective patient support.
Readability levels exceed recommended guidelines, posing a barrier for Spanish-speaking patients seeking cancer information.