Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoluminescence: Applications01:14

Photoluminescence: Applications

Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Triptolide protects rat heart against pressure overload-induced cardiac fibrosis.

International journal of cardiology·2013
Same author

Multiresidue pesticide analysis of botanical dietary supplements using salt-out acetonitrile extraction, solid-phase extraction cleanup column, and gas chromatography-triple quadrupole mass spectrometry.

Analytical chemistry·2013
Same author

Interaction domains of p62: a bridge between p62 and selective autophagy.

DNA and cell biology·2013
Same author

Predictors of seizure freedom after surgical management of tuberous sclerosis complex: a systematic review and meta-analysis.

Epilepsy research·2013
Same author

Temporary ileostomy versus colostomy for colorectal anastomosis: evidence from 12 studies.

Scandinavian journal of gastroenterology·2013
Same author

Localized leptin release may be an important mechanism of curcumin action after acute ischemic injuries.

The journal of trauma and acute care surgery·2013
Same journal

CaMKII in the Heart: From Homeostasis to Pathology.

Annual review of physiology·2026
Same journal

Cerebrospinal Fluid-Mediated Brain Clearance: Insights from Human Studies.

Annual review of physiology·2026
Same journal

The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals.

Annual review of physiology·2026
Same journal

Light Out of Sight: Signaling Mechanisms for Nonvisual Opsins.

Annual review of physiology·2025
Same journal

From Oil Spills to Air Pollution: The Emergence of Phenanthrene as a Ubiquitous Cardiac Toxicant.

Annual review of physiology·2025
Same journal

The Representation of Nociception and Pain in the Developing Brain.

Annual review of physiology·2025
See all related articles

Related Experiment Video

Updated: May 11, 2026

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
10:16

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

7.9K

Interrogating Physiological Functions with Light and Chemicals.

Tianlu Wang1, Kai Zhang2, Yubin Zhou1,3,4

  • 1Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA.

Annual Review of Physiology
|November 10, 2025
PubMed
Summary
This summary is machine-generated.

Optogenetics and chemogenetics offer precise control over biological systems using light or small molecules. These powerful tools advance physiological research and emerging clinical therapies for various diseases.

Keywords:
chemogeneticsimmunotherapyoptogeneticssignal transductionsynthetic biologytherapeutics

More Related Videos

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
08:58

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

4.9K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.8K

Related Experiment Videos

Last Updated: May 11, 2026

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
10:16

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

7.9K
Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
08:58

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

4.9K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.8K

Area of Science:

  • Physiology
  • Molecular Biology
  • Biotechnology

Background:

  • Optogenetics and chemogenetics enable precise control over protein activity and cellular function.
  • Optogenetics utilizes light-sensitive proteins for rapid, localized control.
  • Chemogenetics employs small molecules for systemic, sustained pathway modulation.

Purpose of the Study:

  • To review and categorize optogenetic and chemogenetic tools.
  • To compare their advantages, limitations, and applications.
  • To discuss strategies for enhancing their precision, efficiency, and translation.

Main Methods:

  • Categorization of tools by mechanism of action.
  • Comparative analysis of optogenetic and chemogenetic approaches.
  • Discussion of current and future research and clinical applications.

Main Results:

  • These technologies have significantly advanced research in neuroscience, cardiology, immunology, and gene regulation.
  • Applications span disease models including epilepsy, metabolic disorders, cardiovascular diseases, and cancer.
  • Emerging clinical uses include vision restoration and engineered immune cell therapies.

Conclusions:

  • Optogenetics and chemogenetics are transformative tools for dissecting complex physiological processes.
  • Continued technological evolution promises powerful new approaches for therapeutic interventions.
  • Improving precision, efficiency, and translational capability is key for future development.