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Updated: Jan 11, 2026

Techniques to Induce and Quantify Cellular Senescence
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Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives

Le Liu1,2, Chen Li1,2, Youshuo Liu1,2

  • 1Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Aging and Disease
|November 10, 2025
PubMed

Insights

Epigenetic reprogramming alters regulated cell death (RCD) pathways, driving aging and related diseases. Targeting this epigenetic-RCD axis offers new therapeutic strategies for age-related conditions.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Epigenetics

Background:

  • Aging is linked to complex molecular changes, including epigenetic modifications and altered regulated cell death (RCD).
  • The interplay between epigenetics and RCD in aging is not fully understood.
  • RCD pathways like pyroptosis, ferroptosis, and necroptosis are implicated in age-related diseases.

Purpose of the Study:

  • To conceptualize age-related epigenetic reprogramming as a key regulator of RCD pathways.
  • To explore the role of the epigenetic-RCD axis in the pathophysiology of major aging-related diseases.
  • To examine therapeutic strategies targeting the epigenetic-RCD axis.

Main Methods:

  • Systematic review and synthesis of existing evidence on epigenetic modifications and RCD.
  • Analysis of how DNA methylation, histone modifications, and non-coding RNAs influence RCD networks.
  • Conceptual framework development linking epigenetics, RCD, and aging.

Main Results:

  • Age-related epigenetic reprogramming acts as a master switch for RCD pathways.
  • The epigenetic-RCD axis drives the pathology of diabetes, neurodegenerative disorders, cardiovascular diseases, and cancer.
  • Specific epigenetic mechanisms (DNA methylation, histone modifications, RNA methylation) intricately control RCD.

Conclusions:

  • The epigenetic-RCD axis provides a novel paradigm for understanding aging.
  • Targeting this axis presents therapeutic opportunities for age-related diseases.
  • Further research is needed to address translational challenges for intervention strategies.

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