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Updated: Jan 11, 2026

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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NCCN Guidelines® Insights: Breast Cancer, Version 5.2025.

William J Gradishar1, Meena S Moran2, Jame Abraham3

  • 11Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

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|November 10, 2025
PubMed
Summary
This summary is machine-generated.

NCCN Guidelines Insights highlight recent updates for invasive breast cancer management. Recommendations cover workup, therapy, and surveillance for nonmetastatic disease based on version 5.2025.

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Area of Science:

  • Oncology
  • Clinical Guidelines

Background:

  • The treatment of invasive early-stage and metastatic breast cancer is rapidly evolving.
  • Clinical practice requires up-to-date guidance for optimal patient care.

Purpose of the Study:

  • To summarize key updates in the NCCN Guidelines for Breast Cancer (version 5.2025).
  • To provide insights into recent changes in the management of invasive, nonmetastatic breast cancer.

Main Methods:

  • Review of the NCCN Guidelines for Breast Cancer, version 5.2025.
  • Focus on updates related to workup, locoregional therapy, surveillance, and systemic therapy.

Main Results:

  • The latest NCCN Guidelines include updated recommendations for invasive breast cancer.
  • Specific changes address diagnostic workup, surgical and radiation approaches, patient monitoring, and neoadjuvant/adjuvant systemic treatments.

Conclusions:

  • Version 5.2025 of the NCCN Guidelines offers current recommendations for invasive, nonmetastatic breast cancer.
  • These updates are crucial for oncologists managing breast cancer patients.