Related Experiment Video

Updated: Jan 11, 2026

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

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Role of TREM2 in neuroinflammation

Altaf A Abdulkhaliq1, Glowi Alasiri2, Yousef M Almoghrabi3

  • 1Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.

Experimental Neurology
|November 10, 2025
PubMed

Insights

Triggering receptor expressed on myeloid cells 2 (TREM2) on microglia is crucial for neuroinflammation in CNS disorders. Understanding TREM2 signaling offers new therapeutic targets for neurodegenerative diseases.

Area of Science:

  • Neuroscience
  • Immunology

Background:

  • Triggering receptor expressed on myeloid cells 2 (TREM2) is a key microglial receptor in the central nervous system (CNS).
  • TREM2 plays a significant role in modulating neuroinflammatory responses.

Purpose of the Study:

  • To review the molecular mechanisms of TREM2 in regulating neuroinflammation.
  • To highlight recent advances in TREM2-mediated signaling.

Main Methods:

  • Literature review focusing on TREM2 function in neuroinflammation.
  • Analysis of recent studies on TREM2 signaling pathways.

Main Results:

  • TREM2 influences inflammatory signaling pathways in microglia.
  • Dysregulation of TREM2 is implicated in neurodegenerative and CNS disorders.

Conclusions:

  • TREM2 is a critical regulator of neuroinflammation.
  • Further understanding of TREM2 signaling may reveal novel therapeutic strategies for CNS diseases.
Keywords:
Alzheimer's and Parkinson's diseasesBrain hemorrhageMicrogliaNeurodegenerative diseasesNeuroinflammationTREM2

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