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Updated: Jan 11, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
Published on: January 12, 2012
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Haixin Liu1, Riccardo Melani1, Marta Maltese1
1Neuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
Abstract:
Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson's disease.
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