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Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis

Xinpeng Hou1,2, Xiumei Mo1, Xiaoran Zhang1

  • 1Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.

Parasites & Vectors
|November 11, 2025
PubMed
Summary

Cuproptosis, a copper-dependent cell death, worsens cerebral malaria (CM) by increasing astrocyte reactivity. Modulating copper levels may offer a new therapeutic strategy for CM.

Keywords:
AstrocyteBlood–brain barrierCerebral malariaCuproptosis

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