Related Experiment Video

Updated: Jan 11, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.3K

Diabetic cardiomyopathy: a comprehensive review of diagnosis, management, and future directions

Bhagyalakshmi Balakrishnan1, Divyashree M Somashekara1, Veena Nayak2

  • 1Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

Diabetology & Metabolic Syndrome
|November 11, 2025
PubMed

Insights

Diabetic cardiomyopathy, characterized by heart changes and dysfunction, poses a significant health challenge. This review explores current and novel diagnostic and treatment strategies for this diabetes complication.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomedical Research

Background:

  • Diabetic cardiomyopathy (DCM) is a distinct cardiac pathology in diabetes, leading to fibrosis, hypertrophy, and heart failure.
  • Diagnosis is challenging, necessitating advanced imaging and specialized techniques beyond routine tests.
  • Current treatments primarily manage diabetes and its complications, often inadequately addressing DCM directly.

Purpose of the Study:

  • To review current diagnostic and therapeutic approaches for diabetic cardiomyopathy.
  • To evaluate the benefits and limitations of existing strategies.
  • To explore novel diagnostic biomarkers and therapeutic interventions, including gene therapy and RNA-mediated regulation.

Main Methods:

  • Comprehensive literature review of diagnostic tools (echocardiography, MRI, PET) and treatments (GLP-1 modulators, SGLT-2 inhibitors).
  • Analysis of emerging therapies like gene therapy and noncoding RNA.
  • Discussion of biomarkers for screening, diagnosis, and treatment response.

Main Results:

  • Current diagnostic methods provide insights but face limitations in early detection.
  • Standard treatments focus on glycemic control and complication management.
  • Novel approaches like gene therapy and RNA-based strategies show promise for targeted DCM intervention.

Conclusions:

  • Diabetic cardiomyopathy requires integrated diagnostic and therapeutic strategies.
  • Advancements in biomarkers and novel therapies offer potential for improved patient outcomes.
  • Further research is crucial for effective management and prevention of diabetic cardiomyopathy.

Keywords:
Diabetic cardiomyopathyGLP1Heart failureHypertrophySGLTiVentricular dysfunction

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

571
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
451
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
323
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
438
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
380
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
488
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
305