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Updated: Jan 11, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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Theta Burst Stimulation as a tool to decrease drinking in treatment-seeking alcohol users: study protocol for a

Kaitlin R Kinney1, Haley A Kirse1,2, Nathanial E Stewart1

  • 1Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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|November 11, 2025
PubMed
Summary
This summary is machine-generated.

This study investigates transcranial magnetic stimulation (TMS) for alcohol use disorder (AUD), comparing treatments targeting the dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (MPFC). The goal is to reduce alcohol consumption and craving.

Keywords:
Alcohol use disorderFunctional MRIIntermittent theta burst stimulationTranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Alcohol use disorder (AUD) presents significant challenges with limited treatment success.
  • Non-invasive neuromodulation, specifically transcranial magnetic stimulation (TMS), shows promise for AUD treatment.
  • Previous research suggests TMS can modulate brain circuits critical to AUD, but optimal targets require further investigation.

Purpose of the Study:

  • To evaluate the efficacy of intermittent theta burst stimulation (iTBS) applied to the dorsolateral prefrontal cortex (DLPFC) versus the medial prefrontal cortex (MPFC) in treating AUD.
  • To assess the impact of iTBS on alcohol consumption, craving, and neural responses to alcohol cues.
  • To compare two distinct cortical targets for TMS intervention in a single, rigorous clinical trial.

Main Methods:

  • A randomized, double-blind, sham-controlled trial involving 180 individuals with AUD.
  • Participants receive real iTBS to either the MPFC or DLPFC, or sham iTBS.
  • Treatment involves 30 sessions over 3-6 weeks, with pre/post MRI scans and 3-month follow-up.

Main Results:

  • This section is to be filled after the study is completed.

Conclusions:

  • This trial aims to provide crucial insights for optimizing TMS protocols for AUD treatment.
  • Findings may inform the development of standardized TMS protocols, potentially supporting FDA approval.
  • The study seeks to advance TMS as a viable intervention for AUD, improving treatment efficacy and patient outcomes.