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Related Experiment Video

Updated: Jan 11, 2026

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Alterations in Cardiovascular Parameters in 5xFAD Murine Model.

Andrea G Marshall1, Dominique Stephens1,2, Kit Neikirk1

  • 1Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

Cell Biochemistry and Function
|November 11, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) in mice showed few cardiovascular changes at a young age. Further studies at later ages are needed to understand AD's impact on cardiovascular and cerebrovascular health.

Keywords:
5xFADalzheimer's diseasecardiovascular diseasepulse wave velocity

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Area of Science:

  • Neuroscience
  • Cardiovascular Research
  • Biomedical Engineering

Background:

  • Alzheimer's Disease (AD) is a growing global health concern impacting memory and cognition.
  • AD is linked to cardiovascular risk factors, necessitating research into its systemic effects.
  • The 5xFAD mouse model is used to study AD-related changes.

Purpose of the Study:

  • To measure hemodynamic parameters in 5xFAD mice to assess cardiovascular and cerebrovascular function.
  • To investigate arterial stiffness using cardiovascular pulse wave velocity (PWV) and cerebrovascular PWV.
  • To determine if early-stage AD pathology in mice correlates with measurable cardiovascular changes.

Main Methods:

  • Hemodynamic parameters were measured in 5xFAD mice and littermate controls.
  • Cardiovascular pulse wave velocity (PWV) was assessed as a marker of arterial stiffness.
  • Cerebrovascular PWV was measured using a novel technique to assess cerebral arterial stiffness.

Main Results:

  • 5xFAD mice showed significant differences in ejection time, pulse pressure, and Tei index compared to controls.
  • Many other cardiovascular and cerebrovascular parameters, including PWV, did not differ significantly.
  • No significant cardiovascular changes were observed despite early amyloid plaque deposition in young 5xFAD mice.

Conclusions:

  • Early-stage AD in 5xFAD mice does not profoundly affect most measured cardiovascular and cerebrovascular parameters.
  • Further research at later ages is recommended to explore more significant parametric changes associated with advanced AD.
  • Understanding the interplay between AD and cardiovascular health requires age-specific investigations.