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Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

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Published on: August 4, 2017

Engineering Hollow Hydrogel Architectures toward Cutting-Edge Applications.

Qing Chen^1,2, Shumin Liang^1,3, Tao Chen⁴

¹School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

Advanced Healthcare Materials

|November 11, 2025

Summary

This summary is machine-generated.

This review explores advanced methods for creating hollow hydrogels, focusing on chemical reactions and 3D printing for applications in medicine and tissue engineering.

Keywords:

3D printing aqueous‐phase chemical reactions film‐to‐tube transformation hollow hydrogels medical catheters tissue engineering

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Published on: July 18, 2018

Area of Science:

Biomaterials Science
Chemical Engineering
Biotechnology

Background:

Traditional 3D printing of hollow structures faces limitations in resolution and biocompatibility due to curing processes.
Aqueous-phase chemical reactions offer a template-free method for high-resolution hollow hydrogel fabrication with enhanced mechanical properties.

Purpose of the Study:

To comprehensively analyze and compare chemical reaction-driven assembly and 3D printing for hollow hydrogel fabrication.
To evaluate the design principles, advantages, and limitations of each fabrication strategy.
To explore the applications of hollow hydrogels in drug delivery, tissue engineering, and biosensing.

Main Methods:

Review of literature on aqueous-phase chemical reactions for hydrogel formation.
Analysis of 3D printing technologies for hollow structure fabrication.
Systematic comparison of fabrication methods based on resolution, mechanical strength, and geometric control.

Main Results:

Aqueous-phase chemical methods provide superior resolution and mechanical strength.
3D printing offers precise control over customized geometries.
Incorporating living cells into hollow hydrogels remains a significant challenge.

Conclusions:

Hollow hydrogels fabricated via aqueous-phase chemistry offer advantages in resolution and strength, while 3D printing excels in geometric customization.
Future research should focus on overcoming cell incorporation challenges to bridge structural engineering with clinical translation for applications in drug delivery, tissue engineering, and biosensing.