Related Experiment Video
Updated: Jan 11, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Effects of Nitric Oxide on Hemodynamics After Transcatheter Mitral Valve Repair Complicated by Pulmonary
Ryotaro Tani1, Takuma Iwaya1, Naohiko Nakanishi1
1Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Kyoto Japan.
Background:
Elevated pulmonary arterial pressure (PAP) is associated with poor prognosis in patients with functional mitral regurgitation (MR) undergoing transcatheter mitral valve repair (TMVr). Nitric oxide (NO) inhalation therapy reduces PAP and pulmonary vascular resistance (PVR) after open-heart surgery, but its efficacy in patients with pulmonary hypertension (PH) undergoing catheter intervention remains unclear.
Methods And Results:
This open-label, interventional, randomized controlled trial will investigate the efficacy of NO inhalation therapy after TMVr for MR complicated by PH. A total of 40 patients aged ≥18 years diagnosed with PH (mean PAP >20 mmHg) during preoperative right heart catheterization and scheduled for TMVr for MR are included in this study. Patients receiving pulmonary vasodilators, with NO contraindications, and with unstable conditions requiring intravenous catecholamines or mechanical circulatory support devices are excluded. Eligible patients are randomly allocated to the NO inhalation or control group in a 1 : 1 ratio. NO (20 ppm) is administered post-TMVr (D0) until the day after TMVr (D1). The control group is administered oxygen as necessary. The primary endpoint is the change in PVR (baseline to D1). The secondary endpoints include changes in cardiac index and mean PAP (baseline to D1), changes in PVR immediately before NO administration post-TMVr to D1, and postoperative complication rates.
Conclusions:
This study will assess the efficacy of NO inhalation in patients with PH undergoing TMVr for MR.
Related Concept Videos
Mitral Stenosis IV: Nursing Management
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management
Mitral Stenosis I: Introduction
Mitral Regurgitation III: Medical Management
Mitral Regurgitation IV: Nursing Management

