The influence of early nutrition intake and clinical factors on the brain development of preterm infants with intrauterine growth restriction
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View abstract on PubMed
Summary
This summary is machine-generated.Intrauterine growth restriction (IUGR) in preterm infants is linked to delayed brain development. Early protein intake and specific biological indicators are associated with better cerebral growth at term-equivalent age (TEA).
Area Of Science
- Neonatalogy
- Neuroscience
- Pediatric Nutrition
Background
- Intrauterine growth restriction (IUGR) is a common pregnancy complication.
- Preterm infants with IUGR face increased risks of postnatal brain development delays.
- The early postnatal period is critical for brain growth and highly sensitive to nutritional deficits.
Purpose Of The Study
- To investigate the relationship between clinical factors, including early nutrition, and cerebral growth in preterm infants with IUGR.
- To assess brain development at term-equivalent age (TEA) in relation to specific clinical and nutritional parameters.
- To identify factors influencing brain growth in this vulnerable population.
Main Methods
- Retrospective analysis of clinical data from preterm infants (2015-2019).
- Nutritional assessment focused on protein, fat, carbohydrate, and energy intake during the first postnatal week.
- Cerebral measurements via MRI at TEA, analyzed using multiple regression.
Main Results
- IUGR infants exhibited reduced cerebral measurements (BFD, FH-L/R, TCD, CC) compared to non-IUGR infants.
- Higher protein intake in the first week correlated with larger bifrontal diameter and frontal lobe heights in non-IUGR infants.
- Various biological indicators (e.g., growth parameters, gestational age, birth weight, GDM, RDS, IVH) were associated with regional brain development at TEA.
Conclusions
- Preterm infants with IUGR are at higher risk for delayed brain development at TEA.
- Early nutritional intake, particularly protein, and specific biological indicators are crucial for brain development in preterm infants.
- Gestational age, birth weight, feeding duration, and conditions like GDM, RDS, and IVH significantly impact brain region development.
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