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Effects of modified exchange blood transfusion therapy on infants with severe pertussis: a case-control study
Rulin Huang1, Yi Qin1, Lan Ma1
1Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Insights
Modified exchange blood transfusion (ET) significantly reduced mortality in severe pertussis cases among children. This treatment also led to favorable changes in key laboratory indicators, highlighting its effectiveness.
Area of Science:
- Pediatrics
- Infectious Diseases
- Hematology
Background:
- Severe pertussis predominantly affects children, posing a significant health risk.
- Modified exchange blood transfusion (ET) offers potential benefits but is underutilized in pediatric severe pertussis.
- The efficacy and nursing considerations of ET in severe pertussis require further elucidation.
Purpose of the Study:
- To investigate the effects of modified exchange blood transfusion (ET) on severe pertussis in children.
- To summarize essential nursing interventions for ET in pediatric severe pertussis cases.
Main Methods:
- A case-control study was conducted involving infants with severe pertussis.
- Patients were divided into an ET group (receiving modified ET) and a control group (not receiving ET).
- Demographic data, clinical signs, laboratory results, imaging, and outcomes were analyzed.
Main Results:
- The overall mortality rate for severe pertussis was 38.7%.
- The ET group exhibited a significantly lower mortality rate (16.7%) compared to the control group (52.6%).
- ET group patients showed significant reductions in white blood cell count, absolute lymphocyte count, platelet count, and heart rate.
Conclusions:
- Modified exchange blood transfusion (ET) demonstrates effectiveness in treating severe pertussis in children.
- ET can significantly decrease the mortality rate associated with severe pertussis.
- Careful preoperative preparation, vigilant monitoring, and prompt interventions are crucial to minimize ET complications.
Background:
Severe pertussis usually occurs in children. The modified exchange blood transfusion (ET) has some benefits, but has not been widely used in children with severe pertussis. Therefore, the effects of ET on severe pertussis are to be illustrated. This study aimed to investigate the effects of ET on severe pertussis in children, and summarize the key points of nursing.
Methods:
A case-control study of infants with severe pertussis in a tertiary hospital in south China from January 2018 to December 2019 was conducted. Severe pertussis children receiving modified ET were included in the ET group, while those without modified ET were selected into the control group. The demographics, symptoms and signs, laboratory indicators, imaging examination, and outcomes were collected and analyzed.
Results:
The total mortality rate of severe pertussis children was 38.7% (12/31). The mortality rate was 16.7% (2/12) in the ET group, and 52.6% (10/19) in the control group (P<0.05). White blood cell count, absolute lymphocyte count, platelet count, and heart rate of the ET group significantly decreased (P<0.05).
Conclusions:
Modified ET was effective in severe pertussis and could decrease the mortality rate. Close attention to preoperative preparations, observation, and timely intervention could reduce the occurrence of complications of modified ET.
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