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NHC-Boryl Radical-Catalyzed [3 + 2] Cycloaddition for the Synthesis of Vinylcyclopentanes

Yee Lin Phang1, Yan Liu1, Jie Wang1

  • 1State Key Laboratory of Precision and Intelligent Chemistry, Anhui Provincial Key Laboratory of Biomass Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.

The Journal of Organic Chemistry
|November 11, 2025
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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