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Updated: Jan 11, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Environment-Responsive Self-Assembly and Coupled-Network Effect in Dynamic Replicating Nucleopeptide Networks.

Yingjie Huang1, Yushun Zhou1, Yulu Wang1

  • 1School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.

Angewandte Chemie (International Ed. in English)
|November 11, 2025
PubMed
Summary

Researchers created adaptive, self-replicating nucleopeptide networks that respond to environmental changes. These dynamic systems demonstrate how molecular interactions drive complex behaviors and signal transmission in chemical systems.

Keywords:
Dynamic combinatorial libraryNucleopeptide networksSelf‐assemblySelf‐replicationSystems chemistry

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Area of Science:

  • Chemical Systems Biology
  • Supramolecular Chemistry
  • Origin of Life Studies

Background:

  • Complex adaptive behaviors in chemical systems arise from coupled reaction networks and self-organization.
  • Self-replicating systems are key to understanding temporally evolving, system-level behaviors driven by molecular interactions.
  • Previous research often focused on static, single-component systems, neglecting multicomponent dynamics and inter-network coupling.

Purpose of the Study:

  • To investigate dynamic nucleopeptide networks for environment-responsive self-assembly and self-replication.
  • To explore nonlinear interspecies dynamics and inter-network coupling in multicomponent chemical systems.
  • To establish a framework for designing adaptive, life-like chemical systems that interact with their environment.

Main Methods:

  • Investigated dynamic nucleopeptide networks composed of nucleobases and short peptides.
  • Analyzed environment-responsive self-assembly and self-replication under varying conditions (pH, temperature, ionic strength).
  • Utilized base-specific recognition for hierarchical network coupling to transmit environmental signals.

Main Results:

  • Demonstrated dynamic synergy between nucleobases and peptides, forming organized, self-replicating structures.
  • Revealed orchestration of cooperative and competitive species for adaptation to environmental parameters.
  • Showcased hierarchical network coupling for transmitting environmental signals between systems.

Conclusions:

  • Nucleopeptide networks exhibit dynamic adaptation and environment-responsive self-assembly.
  • Inter-network coupling enables signal transmission, mimicking communication in biological systems.
  • Findings provide insights into temporal and cross-network regulation for designing adaptive chemical systems.