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Updated: Jan 11, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Photodynamic mechanistic regulation of conjugated polymers for synergistic photodynamic-chemotherapy
Hankun Zhang1, Qiang Cheng1, Hongyan An1
1College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China. benhuawang@csu.edu.cn.
Abstract:
In this work, we report a side-chain engineering strategy to switch photodynamic pathways of poly(p-phenylene ethynylene) (PPE) derivatives. Neutral PPE1 lacks photosensitivity, cationic PPE2 selectively generates singlet oxygen (1O2) via a type-II mechanism, while zwitterionic PPE3 produces superoxide anions (O2-˙) through a type-I process. Notably, side-chain functionalization concurrently modulates their platinum (Pt)-binding affinities. The resulting PPE3-Pt nanoplatform undergoes DNA-triggered Pt release, restoring ROS generation and enabling synergistic chemo-photodynamic therapy.
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