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Related Experiment Video

Updated: Jan 11, 2026

Determining Bile Duct Density in the Mouse Liver
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Multimarker Model Enhances Diagnostic Accuracy in Biliary Stricture Determination: Meta-Analysis Validation.

Yu Jin1, Qi He1, Guochen Shang1

  • 1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical and Translational Gastroenterology
|November 11, 2025
PubMed
Summary

Biliary carcinoembryonic antigen (BCEA) and carbohydrate antigen 19-9 (BCA19-9) show superior diagnostic value for biliary strictures. A combined model using these markers significantly improves accuracy in differentiating benign from malignant cases.

Keywords:
biliary stricturebiliary tumor markerscarbohydrate antigen 19-9carcinoembryonic antigendiagnostic modelmeta-analysis

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Area of Science:

  • Gastroenterology and Hepatology
  • Oncology
  • Biomarker Research

Background:

  • Biliary strictures pose diagnostic challenges, requiring accurate differentiation between benign and malignant etiologies.
  • Early and precise diagnosis is crucial for effective patient management and treatment planning.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum and biliary carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) for biliary strictures.
  • To develop and validate a combined diagnostic model integrating these tumor markers.

Main Methods:

  • A retrospective cohort study of 268 patients undergoing ERCP for biliary strictures.
  • Measurement of serum (SCEA, SCA19-9) and biliary (BCEA, BCA19-9) CEA and CA19-9 levels.
  • Development of a combined diagnostic model using ROC analysis and logistic regression, validated by meta-analysis of 7 studies.

Main Results:

  • BCEA and BCA19-9 levels were significantly higher in malignant cases compared to serum levels.
  • The combined model achieved high diagnostic performance (AUC 0.921 training, 0.911 validation) with good sensitivity and specificity.
  • Meta-analysis confirmed significant diagnostic efficacy (pooled OR 25.65, sensitivity 95.0%, specificity 83.7%).

Conclusions:

  • BCEA and BCA19-9 are superior markers for distinguishing benign from malignant biliary strictures.
  • The multimarker model integrating serum and biliary markers enhances diagnostic accuracy.
  • Further research on optimizing marker cutoff values is recommended for improved precision.