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Updated: May 11, 2026
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Published on: January 30, 2014
Post-translational modifications regulating microglial inflammation in central nervous system disorders: a review
Xueqi Wang1, Mei Yang1, Yusong Wang1
1Department of Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Post-translational modifications (PTMs) regulate microglia, the brain's immune cells. Understanding seven key PTMs offers insights into neuroinflammation and potential therapeutic targets for neurological diseases.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Microglia are key immune cells in the central nervous system, crucial for neuroinflammation and neural homeostasis.
- Post-translational modifications (PTMs) critically regulate microglial functions, including inflammatory responses and phagocytosis.
Purpose of the Study:
- To review the role of seven specific PTMs in modulating microglial inflammation.
- To explore the potential of these PTMs as therapeutic targets for neuroinflammatory diseases.
Main Methods:
- Literature review focusing on PTMs and microglial function.
- Analysis of how PTMs influence microglial phenotypes in central nervous system diseases.
Main Results:
- Seven PTMs (phosphorylation, acetylation, methylation, ubiquitination, succinylation, SUMOylation, lactylation) are closely linked to microglial inflammation.
- These PTMs significantly shape microglial phenotypes in neuroinflammatory contexts.
- PTMs represent promising therapeutic targets for treating inflammation-driven neuropathologies.
Conclusions:
- Understanding PTMs in microglia provides critical insights into neuroinflammation.
- This review summarizes PTM-mediated regulation of microglial function for future research.
- Targeting PTMs may offer novel strategies for neurological disease treatment.
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