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Magnesium-Loaded Collagen/Hyaluronic Acid-Catechol Hydrogel Cross-Linked by Visible Light for Infected Wound Healing
Yu-Jin Kim1, Yerim Song1,2, Goeun Choe1
1Biomaterials Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
ACS Applied Bio Materials
|November 11, 2025
Summary
This study developed a magnesium ion-infused collagen hydrogel that effectively combats bacterial infections in wounds. This innovative wound dressing promotes faster tissue regeneration and offers a safer alternative to traditional treatments.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Skin wounds are susceptible to bacterial infections, delaying healing.
- Conventional treatments have limitations like toxicity and antibiotic resistance.
- Effective antibacterial strategies are crucial for wound regeneration.
Purpose of the Study:
- To design a visible light-cross-linked collagen hydrogel with antibacterial properties.
- To incorporate magnesium ions (Mg2+) for enhanced wound treatment.
- To evaluate the hydrogel's efficacy in infected wound models.
Main Methods:
- Developed a collagen-based hydrogel cross-linked by visible light.
- Incorporated magnesium ions (Mg2+) into the hydrogel matrix.
- Assessed antibacterial activity against Staphylococcus aureus and evaluated wound healing in a mouse model.
Main Results:
- The Mg2+-loaded hydrogel demonstrated excellent biocompatibility and tissue adhesion.
- Achieved approximately 70% inhibition of Staphylococcus aureus growth.
- Effectively suppressed bacterial growth and accelerated wound healing in a full-thickness skin defect mouse model.
Conclusions:
- The Mg2+-loaded collagen-hyaluronic acid hydrogel shows significant antibacterial activity.
- This hydrogel platform offers integrated antibacterial efficacy, tissue adhesion, and regenerative potential.
- Represents a promising therapeutic approach for treating infected wounds.
