Related Experiment Video

Updated: Jan 11, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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NR1D1 in tumorigenesis: dual roles, mechanisms, and therapeutic targeting

Zhuangwei Lv1, Ruohao Yang2, Jinhua Wu3

  • 1School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China.

Gene
|November 11, 2025
PubMed

Insights

Nuclear receptor subfamily 1, group D, member 1 (NR1D1) has dual roles in cancer, acting as a tumor suppressor or oncogene. This review explores NR1D1

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Chronobiology

Background:

  • Nuclear receptor subfamily 1, group D, member 1 (NR1D1), also known as REV-ERBα, is a core circadian regulator.
  • NR1D1 exhibits context-dependent dual roles in cancer, functioning as either a tumor suppressor or an oncogene.
  • Understanding NR1D1's complex role is crucial for developing novel cancer therapies.

Purpose of the Study:

  • To synthesize current evidence on NR1D1's regulation of key oncogenic pathways in cancer.
  • To highlight NR1D1's potential as a prognostic biomarker and therapeutic target.
  • To discuss challenges and opportunities in targeting NR1D1 for cancer treatment.

Main Methods:

  • Comprehensive literature review of studies investigating NR1D1 in cancer.
  • Analysis of NR1D1's involvement in DNA repair, immunomodulation, metabolism, and signaling pathways (PI3K/AKT, JAK/STAT).
  • Evaluation of preclinical data for pharmacological NR1D1 modulators.

Main Results:

  • NR1D1 regulates critical oncogenic pathways including DNA repair, cGAS-STING and NLRP3 inflammasome pathways, metabolism, and PI3K/AKT and JAK/STAT signaling.
  • Pharmacological modulators of NR1D1 have demonstrated preclinical efficacy.
  • NR1D1 serves as a potential prognostic biomarker in various cancers.

Conclusions:

  • NR1D1 is a significant regulator in cancer development and progression, with potential as both a biomarker and therapeutic target.
  • Targeting NR1D1, particularly through combination therapies, offers promising new avenues for cancer treatment.
  • Further research is needed to overcome challenges in NR1D1-targeted therapies.
Keywords:
CancerImmunotherapyMetabolismNLRP3NR1D1

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