Related Experiment Video
Updated: Jan 11, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Use of Corticosteroids in Children with Bell's Palsy: A Systematic Review and Meta-Analysis
Fabian Peralta1, José Manuel Morales-Puebla2,3,4, Roman Pati5
1Universidad Peruana Unión, Lima, Peru.
Insights
Corticosteroid monotherapy may improve recovery for children with acute Bell's palsy beyond one month. This treatment shows potential for reducing incomplete recovery risks, supporting its use in pediatric treatment protocols.
Area of Science:
- Pediatric Neurology
- Clinical Otolaryngology
Background:
- Bell's palsy affects facial nerve function in children, with corticosteroid efficacy debated.
- Current guidelines recommend corticosteroids for adults, but pediatric data is limited.
Purpose of the Study:
- To evaluate the effectiveness of corticosteroid therapy for acute Bell's palsy in pediatric patients.
- To determine optimal timing and regimens for corticosteroid use in children.
Main Methods:
- Systematic review and meta-analysis of 11 studies involving 750 children with acute Bell's palsy.
- Pooled analysis of odds ratios and risk ratios using R software; risk of bias assessed with RoB2 and ROBINS-I.
Main Results:
- No significant difference in overall recovery rates, but corticosteroid monotherapy showed improved complete recovery rates beyond 1 month.
- A reduced risk of incomplete recovery was observed with monotherapy after 6 months.
- Subgroup analyses explored monotherapy versus adjunctive therapies.
Conclusions:
- Corticosteroid monotherapy may enhance recovery in children with acute Bell's palsy after the initial month.
- Findings support considering corticosteroid monotherapy in pediatric Bell's palsy treatment protocols.
Abstract:
Importance: Corticosteroids are recommended as first-line treatment for adults with acute Bell's palsy, but their role in children remains uncertain. Objective: To assess the effect of corticosteroid therapy on recovery rates in children with acute Bell's palsy. Evidence Review: PubMed, Scopus, and Cochrane Library were systematically searched from inception to April 2, 2025, for studies on corticosteroids for children with Bell's palsy. Odds ratios and risk ratios with 95% confidence intervals were pooled using R software (version 4.2.3). Risk of bias was assessed with RoB2 and ROBINS-I. Findings: Eleven studies were included, comprising 750 children, of whom 495 (66%) received corticosteroids. The analysis across final follow-ups showed no significant difference. Because follow-ups ranged from 1 to 24 months, 1, 3, and 6 months were used as key points to create comparable intervals. The following subgroups were analyzed for each interval: corticosteroid monotherapy and corticosteroids plus adjunctive therapy. Corticosteroid monotherapy was associated with higher complete recovery rates beyond 1 month and a lower risk of incomplete recovery after 6 months. Conclusions and Relevance: Corticosteroid monotherapy in children with acute Bell's palsy may improve recovery rates beyond the first month, supporting its implementation in treatment protocols.
Related Concept Videos
COPD: Management Using Bronchodilators and Corticosteroids
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Tonsillitis II: Management
Skeletal Muscle Relaxants: Therapeutic Uses
