Healthcare providers' preferences for pediatric pneumococcal vaccination recommendations in the United States

Jeffrey Vietri1, Kelley Myers2, Liping Huang1

  • 1Pfizer Inc., Collegeville, PA, USA.

Expert Review of Vaccines
|November 11, 2025
PubMed

Insights

Healthcare providers prefer the 20-valent pneumococcal conjugate vaccine (PCV20) for children due to its broader serotype coverage. Most favor transitioning to or adding PCV20 in pediatric vaccination schedules.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health

Background:

  • A 20-valent pneumococcal conjugate vaccine (PCV20) is now available for pediatric use in the US.
  • Pneumococcal conjugate vaccines are crucial for preventing invasive pneumococcal disease in children.

Purpose of the Study:

  • To evaluate healthcare providers' (HCPs) preferences regarding the use of PCV20 in children.
  • To gauge HCP opinions on potential modifications to pediatric pneumococcal vaccination guidelines.

Main Methods:

  • An online survey was administered to 623 HCPs (pediatricians, family physicians, PAs, NPs).
  • Participants had recently prescribed, recommended, or administered pneumococcal vaccines to children.
  • Direct-elicitation questions assessed preferences for PCV20 use in pediatric populations.

Main Results:

  • A significant majority of HCPs (76%) favored transitioning children from PCV13/15 to PCV20.
  • Most HCPs (≥60%) supported a supplemental PCV20 dose for fully vaccinated young children.
  • PCV20 was preferred over PCV15 by 93% of HCPs for children up to 18 years.

Conclusions:

  • HCPs demonstrated a clear preference for PCV20 in clinical practice and recommendations.
  • The preference for PCV20 is driven by its expanded coverage of pneumococcal serotypes.
Abstract

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