Rapid evaporative ionization mass spectrometry in surgery: a systematic review
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View abstract on PubMed
Summary
This summary is machine-generated.Rapid evaporative ionization mass spectrometry (REIMS) shows promise for real-time surgical tissue identification. While ex vivo studies are abundant, further in vivo research is needed to overcome logistical challenges and support wider clinical adoption.
Area Of Science
- Surgical Technology
- Biomedical Engineering
- Analytical Chemistry
Background
- Rapid evaporative ionization mass spectrometry (REIMS) is an emerging technology for real-time intraoperative tissue identification.
- This review synthesizes the applications and outcomes of REIMS in surgical settings.
Purpose Of The Study
- To systematically review the applications and reported outcomes of REIMS technology in surgery.
- To identify current limitations and future research directions for REIMS in clinical practice.
Main Methods
- A systematic review of four databases (MEDLINE, Emcare, Embase, Web of Science) was conducted.
- Studies published in peer-reviewed journals, involving five or more patients, and evaluating REIMS in surgical contexts were included.
- Risk of bias was assessed using the QUADAS-2 tool, with protocol registration in PROSPERO.
Main Results
- Twenty-six studies from seven countries were included, applying REIMS across eight surgical specialties.
- REIMS was predominantly used for cancerous tissue identification, demonstrating promising accuracy, sensitivity, and specificity.
- Both ex vivo and in vivo applications were explored, though in vivo data and logistical considerations present limitations.
Conclusions
- Current evidence for REIMS in surgery largely stems from ex vivo studies.
- Logistical challenges and data interpretation complexity hinder widespread application.
- Further in vivo studies with larger patient cohorts are essential to validate REIMS for broader surgical use.
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