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Updated: Jan 11, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiome in IBD: past, present and the future.
Jingwan Zhang1, Joyce Wing Yan Mak1, Siew C Ng2,3
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Gut
|November 11, 2025
Summary
Inflammatory bowel disease (IBD) is linked to gut microbiome changes. Research explores how microbes, genetics, and environment impact IBD, seeking new diagnostic and treatment strategies.
Area of Science:
- Gastroenterology and Microbiology
- Host-Microbiome Interactions
- Inflammatory Bowel Disease (IBD) Research
Background:
- IBD is a growing global health concern.
- Gut microbiome alterations (bacteria, fungi, viruses) are implicated in IBD pathogenesis.
- Understanding host-microbiota interactions is crucial for IBD management.
Purpose of the Study:
- To review the evolution of microbiome research in IBD.
- To highlight the role of genetic and environmental factors on the gut microbiota.
- To explore cross-kingdom microbiome contributions and therapeutic strategies for IBD.
Main Methods:
- Review of recent advances in sequencing technologies.
- Integration of multi-omics data.
- Analysis of experimental approaches in host-microbiota research.
Main Results:
- Microbiota and their metabolites significantly contribute to IBD development.
- Genetic and environmental factors influence the gut microbiota composition.
- Cross-kingdom interactions within the microbiome play a key role in disease.
Conclusions:
- Microbiome-based approaches offer potential for IBD diagnosis, monitoring, prevention, and treatment.
- Further research into host-microbiota interactions is vital for advancing IBD care.
- Targeting the gut microbiome presents a promising therapeutic avenue for IBD.
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