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Published on: June 13, 2017
Factors Influencing Voice Outcomes After Intracordal Trafermin Injection in Age-Related Vocal Fold Atrophy
Tomohiro Hasegawa1, Yusuke Watanabe2
1Tokyo Voice Center, International University of Health and Welfare, Tokyo, Japan; Department of Epidemiology and Social Medicine, Graduate School of Public Health, International University of Health and Welfare, Tokyo, Japan.
Pre-treatment voice measures predict vocal improvement after intracordal trafermin injections for age-related vocal fold atrophy. Baseline voice data, including maximum phonation time and pitch range, are key indicators of successful outcomes.
Area of Science:
- Otolaryngology
- Speech and Voice Science
Background:
- Age-related vocal fold atrophy (ARVA) causes hoarseness due to degeneration of vocal fold tissues.
- Intracordal trafermin injections are a potential treatment for ARVA.
Purpose of the Study:
- To identify predictors of voice improvement following intracordal trafermin injections for ARVA.
- To evaluate the efficacy of trafermin injections in patients with age-related voice changes.
Main Methods:
- Retrospective study of 181 patients receiving intracordal trafermin injections.
- Analysis of pre- and post-injection voice parameters: maximum phonation time (MPT), pitch range (PR), mean flow rate (MFR), and voice handicap index (VHI).
- Statistical analysis using Welch's t test and analysis of covariance.
Main Results:
- Significant improvements observed in MPT, PR, MFR, and VHI post-injection.
- Post-injection voice parameters were influenced by sex, age, and pre-injection voice data.
- Pre-injection MPT, PR, MFR, and VHI values significantly correlated with post-treatment outcomes.
Conclusions:
- Pre-injection voice parameters are significant predictors of voice improvement after intracordal trafermin injections.
- Baseline voice data can help forecast treatment success in patients with ARVA.
- Intracordal trafermin injections demonstrate efficacy in improving voice quality in ARVA patients.
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