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Sustained low-efficiency dialysis-an old method but possibly a new solution for environmental nephrology
Aleksandra Rymarz1, Filip Wantoch-Rekowski1, Paweł Żebrowski1
1Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Renal Failure
|November 11, 2025
Summary
Slow low-efficiency dialysis (SLED) offers a sustainable kidney replacement therapy. This hybrid technique provides unique advantages in efficacy and safety for intensive care unit patients.
Area of Science:
- Nephrology
- Critical Care Medicine
Background:
- Slow low-efficiency dialysis (SLED) is a hybrid kidney replacement therapy.
- It bridges the gap between intermittent and continuous therapies.
Purpose of the Study:
- To summarize the technical aspects and practical advantages of SLED.
- To present clinical experiences with SLED in challenging critical care scenarios.
- To highlight SLED's unique benefits for intensive care unit (ICU) kidney care.
Main Methods:
- SLED can be performed using mobile batch dialysis systems or standard hemodialysis machines.
- Key features include reduced dialysate flow and extended procedure duration.
Main Results:
- SLED demonstrates efficacy and safety in complex clinical conditions.
- Successful application noted in intraoperative renal replacement therapy during liver transplantation.
- Effective in managing sepsis and heart failure patients with volume overload.
Conclusions:
- SLED offers unique advantages in efficacy, safety, and sustainability for ICU kidney replacement therapy.
- It represents a valuable and sustainable option for critical care nephrology.
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