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Multi-layer encrypted learning for distributed healthcare analytics.

Timothy Kuo1, Hui Yang2

  • 1Complex System Monitoring, Modeling, and Control Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA.

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|November 11, 2025
PubMed
Summary
This summary is machine-generated.

The Internet of Medical Things (IoMT) generates vast health data, raising privacy concerns. This study introduces a privacy-preserving framework using encryption and distributed learning to secure data for accurate healthcare analytics.

Keywords:
Data privacyFederated learningFully homomorphic encryption (FHE)Healthcare analyticsIntensive care units (ICUs)Internet of medical things (IoMT)

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Area of Science:

  • Health Informatics
  • Data Security
  • Machine Learning

Background:

  • The Internet of Medical Things (IoMT) facilitates continuous healthcare data collection, creating data-rich environments.
  • Widespread data distribution across systems raises significant privacy concerns, especially during centralized data aggregation for analysis.
  • Existing methods struggle to balance robust data privacy with the need for accurate analytical insights.

Purpose of the Study:

  • To propose a novel privacy-preserving framework for distributed healthcare analytics on encrypted data.
  • To mitigate data breach risks and privacy violations inherent in large-scale health data processing.
  • To maintain analytical model accuracy while ensuring stringent data privacy.

Main Methods:

  • Implementation of a three-layer protection mechanism for distributed healthcare analytics.
  • Utilization of Fully Homomorphic Encryption (FHE) to encrypt data, enabling computations on ciphertext.
  • Development of a distributed FHE framework supporting iterative learning and a distributed ensemble learning architecture for parallel processing.

Main Results:

  • The proposed framework effectively protects data privacy in real-world intensive care unit (ICU) case studies.
  • Analytical model performance is maintained without compromising data security.
  • The privacy-preserving framework achieved the highest accuracy of 84.6%, outperforming individual departmental models.

Conclusions:

  • The novel framework successfully addresses privacy concerns associated with IoMT data.
  • Distributed FHE and ensemble learning offer a viable solution for secure, collaborative healthcare analytics.
  • This approach avoids centralized data storage, enhancing security and enabling continuous model updates in data-rich healthcare settings.