Epidemiology of moderate-to-severe respiratory syncytial virus infections in children in subtropical Okinawa, Japan: a 4-year retrospective study
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View abstract on PubMed
Summary
This summary is machine-generated.This study identified key risk factors for severe respiratory syncytial virus (RSV) infections in young children in Okinawa, Japan. Younger age, siblings, and underlying diseases were associated with increased severity, informing local prevention strategies.
Area Of Science
- Pediatric Infectious Diseases
- Epidemiology
- Virology
Background
- Respiratory syncytial virus (RSV) is a major cause of severe respiratory illness in infants globally.
- Limited data exists on RSV epidemiology in subtropical regions like Okinawa, Japan.
- This study addresses the need for regional data on RSV in children under five.
Purpose Of The Study
- To characterize the clinical and demographic features of moderate-to-severe RSV infections in children under five in Okinawa.
- To identify risk factors and seasonality of RSV hospitalizations in this subtropical region.
- To provide baseline data for implementing new RSV prevention strategies.
Main Methods
- Retrospective analysis of 1541 hospitalized, laboratory-confirmed RSV cases (April 2017-March 2021).
- Data collected from four hospitals in Okinawa Prefecture.
- Patients classified as moderate or severe based on ICU admission; risk factors and seasonality analyzed.
Main Results
- 7.6% of cases were severe, predominantly in infants under 24 months.
- Younger age, presence of siblings, and multiple underlying diseases were independent risk factors for severe RSV.
- RSV seasonality showed summer peaks (2017-2019), but shifted and broadened in 2020 during COVID-19, with a 62% overall case reduction.
Conclusions
- This study offers a comprehensive assessment of pediatric RSV in Okinawa, a subtropical Japanese setting.
- Identified independent risk factors (younger age, siblings, underlying diseases) for severe RSV.
- Provides crucial baseline data to guide localized RSV prevention strategies, despite not evaluating specific interventions.
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