Related Experiment Video
Updated: Jan 11, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives
Leqing Xu1, Zhao Zhao1, Yufei Zhang2
1Department of Pharmacy, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, PR China.
Abstract:
Emerging evidence underscores the critical role of neuroinflammation and metabolism in the pathophysiology of epilepsy. Metabolic dysregulation and neuroinflammation exacerbate each other, creating a vicious cycle. Although this interplay offers novel insights into the mechanisms underlying neurological disorders and potential therapeutic approaches, its role in epilepsy remains unclear. In this study, we review the interplay between metabolism and neuroinflammation, focusing on glucose, glutamate /γ-aminobutyric acid (GABA), tryptophan-kynurenine, adenosine, and lipid metabolism, aiming to contribute to the development of innovative therapeutic strategies for epilepsy. We also discuss the potential anti-neuroinflammatory and antiepileptic effects of metabolic therapies.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Overview of Metabolism
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Excitatory and Inhibitory Effects of Neurotransmitters

