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Related Experiment Video

Updated: Jan 11, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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Longevity Code: Lipidome Associations and Mediated Metabolite Effects.

Yunfeng Yu1,2, Xinyu Yang1, Juan Deng1

  • 1School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

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|November 12, 2025
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Summary
This summary is machine-generated.

This study used Mendelian randomization to find four ways lipidome affects longevity through metabolites like EDTA and 1-arachidonoyl-gpc. Specific lipids, including sterol ester and phosphatidylcholine, influence lifespan by altering these metabolite levels.

Keywords:
Mendelian randomizationlipidomelongevitymediated effectmetabolites

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Area of Science:

  • Metabolomics
  • Genetics
  • Longevity Research

Background:

  • The interplay between lipidome, metabolites, and human longevity remains incompletely understood.
  • Investigating the causal relationships is crucial for understanding aging processes.

Purpose of the Study:

  • To employ Mendelian randomization (MR) to elucidate the causal impact of the lipidome on longevity.
  • To determine the mediating role of metabolites in the lipidome-longevity association.

Main Methods:

  • Utilized genome-wide association study data for lipidome, metabolites, and longevity.
  • Selected single-nucleotide polymorphisms (SNPs) as instrumental variables for MR analysis.
  • Applied inverse variance weighted (IVW) method for primary analysis and MR-Egger for pleiotropy assessment.

Main Results:

  • Identified four significant lipidome-longevity pathways mediated by metabolites.
  • Sterol ester (27:1/18:3) and triacylglycerol (52:2) were associated with decreased longevity via reduced ethylenediaminetetraacetic acid (EDTA) levels.
  • Triacylglycerol (54:5) showed a link to longevity through altered 1-arachidonoyl-gpc (20:4n6) levels, while phosphatidylcholine (O-16:0_18:2) was linked to increased longevity via elevated EDTA levels.
  • MR-Egger, Cochran's Q, and sensitivity analyses confirmed the robustness and lack of horizontal pleiotropy in the findings.

Conclusions:

  • Four distinct pathways highlight how lipidome influences longevity through specific metabolites.
  • Lipids such as sterol ester, phosphatidylcholine, and triacylglycerols, alongside metabolites EDTA and 1-arachidonoyl-gpc, are implicated as key players in regulating longevity.